منابع مشابه
Peptide-Based Polymer Therapeutics
Polypeptides are envisaged to achieve a major impact on a number of different relevant areas such as biomedicine and biotechnology. Acquired knowledge and the increasing interest on amino acids, peptides and proteins is establishing a large panel of these biopolymers whose physical, chemical and biological properties are ruled by their controlled sequences and composition. Polymer therapeutics ...
متن کاملPeptide-mediated targeted drug delivery.
Targeted drug delivery to specific group of cells offers an attractive strategy to minimize the undesirable side effects and achieve the therapeutic effect with a lower dose. Both linear and cyclic peptides have been explored as trafficking moiety due to ease of synthesis, structural simplicity, and low probability of undesirable immunogenicity. Peptides derived from sequence of cell surface pr...
متن کاملPolymer-wrapped peptide nanotubes: peptide-grafted polymer mass impacts length and diameter.
The external structure of polymer-wrapped nanotubes resembles that of small nanorods with a core/shell morphology, where the core consists of a self-assembled peptide nanotube surrounded by a soft polymeric coat. The length and the diameter of the nanorods are investigated as a function of the molar mass of the peptide-grafted macromolecules by statistical atomic force microscopy cross-section ...
متن کاملDigestive enzyme targeted polymer therapeutic: MIT WO2007103364
The basic claims of this application involve methods that use a polymer to deliver therapeutic molecules in a targeted fashion using a polymeric carrier, drug and a biologically degradable linker. The release of therapeutic molecule is in response to digestive enzymes that are overexpressed in diseased tissues in the body. Further claims, of the sixteen included, define the digestive enzymes an...
متن کاملTargeting tumor angiogenesis: comparison of peptide and polymer-peptide conjugates.
UNLABELLED Endothelial cells in tumor angiogenesis are highly accessible, genetically stable and present unique molecular markers for targeted therapy. Neoplasia is also characterized by enhanced vascular permeability and disordered lymphatics so that both active and passive targeting strategies may play a role in localizing angiogenesis-targeted agents. To investigate the relative importance o...
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ژورنال
عنوان ژورنال: Physiological Research
سال: 2016
ISSN: 1802-9973,0862-8408
DOI: 10.33549/physiolres.933418